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目的：筛选高效、低毒的生物应答反应调节剂。方法：采用淋巴母细胞增殖法、胸腺细胞增殖法、骨髓干细胞增殖法及微量病变抑制法，分别检测了西洋参多糖组份１（ｐｏｌｙｓａｃｃｈａｒｉｄｅｆｒｏｍｐａｎａｘｑｕｉｎｑｕｅｆｏｌｉｕｍ，ＰＰＱ－１－①～④）体外对小鼠脾细胞合成细胞因子的影响。结果：ＰＰＱ－１－①～④虽然单独不能诱导小鼠脾细胞合成ＩＬ－２，但可协同亚适量ＣｏｎＡ（２．５ｍｇ·Ｌ－１）诱导合成ＩＬ－２，其含量为２５０～３００ｕ。另外，这四种多糖也可单独及协同亚适量ＣｏｎＡ（２．５ｍｇ·Ｌ－１）诱导合成ＩＬ－１及ＩＦＮ，ＰＰＱ－１－①～④单独还可明显诱导脾细胞合成ＩＬ－３样活性物质。结论：ＰＰＱ－１－①～④具有一定的免疫调节作用。
Objective: To screen highly effective and less toxic biological response modifiers. METHODS: Lymphocyte proliferation, thymocyte proliferation, bone marrow stem cell proliferation and inhibition of trace lesions were used to detect the synthesis of splenocytes in vitro by polysaccharide from panaxquinquefolium (PPQ-1-1~4). The effect of cytokines. Results: Although PPQ-1-1～4 could not induce mouse spleen cells to synthesize IL-2 alone, it could synthesize IL-2 synergistically with sub-conformable ConA (2.5 mg·L-1) and its content was 250～300u. In addition, these four polysaccharides can also be used to synthesize IL-1 and IFN with a sub-optimal amount of ConA (2.5 mg·L-1), and PPQ-1-1 to 4 alone can also significantly induce the synthesis of IL-3 from spleen cells. Active substances. Conclusion: PPQ-1-1 ~ 4 has a certain degree of immune regulation.