论文部分内容阅读
早在半个多世纪以前人们就认识到,糖尿病(DM)早期往往伴有肾血浆流量(RPF)、肾小球滤过率(GFR)增高及肾小球肥大。近年研究认为,糖尿病时这种肾脏血流动力学变化与糖尿病肾病(diabeticnephropathy,DN)的发生、发展有着非常密切的关系。在DM伴有单侧肾动脉狭窄者中发现,无肾动脉狭窄侧肾脏表现出明显的DN形态学改变,而有肾动脉狭窄侧肾脏病变则不明显;糖尿病大鼠单侧肾切除,发现残余肾灌注及滤过均增加,结果明显加速实验性DN进展,不同蛋白质饮食对DN进展影响的研究发现,高蛋白饮食可使肾小球内高滤过状态更加明显,从而促进肾小球硬化。上述一系列实验有力地提示,肾脏血流动力学异常是促进DN发生、发展的重要因素。因此,探讨DN肾脏血流动力学异常机理,对于防治DN将具有重要的指导意义。本文简述影响DN肾脏血流动力学的因素及其与DN进展的关系。
As early as more than half a century ago, people realized that the early stages of diabetes (DM) are often accompanied by renal plasma flow (RPF), glomerular filtration rate (GFR) increased and glomerular hypertrophy. Recent studies suggest that this diabetic hemodynamic changes and diabetic nephropathy (DN) have a very close relationship. In DM with unilateral renal artery stenosis were found in renal arteries without renal artery stenosis DN showed significant changes in morphology, and renal artery stenosis renal lesions were not obvious; diabetic rats unilateral nephrectomy and found residual Renal perfusion and filtration were increased, the results significantly accelerate the progress of experimental DN, different protein diet on the progress of DN found that high-protein diet can glomerular hyperfiltration state more obvious, thereby promoting glomerular sclerosis. The above series of experiments strongly suggest that abnormal renal hemodynamics is to promote the occurrence and development of DN, an important factor. Therefore, to explore the mechanism of abnormal renal hemodynamics in DN, for the prevention and treatment of DN will have an important guiding significance. This article briefly describes the factors affecting the DN renal hemodynamics and its relationship with the progression of DN.