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目的探究秦皇岛地区新生儿梅毒感染及治疗预后状况。方法选择2013年5月-2015年5月在秦皇岛市妇幼保健院分娩的15 893例新生儿为研究对象,采用TRUST方法与ELISA法检测新生儿的梅毒感染状况。根据患儿的情况采用静脉滴注青霉素或普鲁卡因霉素或头孢曲松(非青霉素类)或氨苄青霉素治疗患儿,观察临床治疗效果。结果15 893例产妇中,167例梅毒抗体阳性产妇(1.05%);167例梅毒抗体阳性产妇分娩的新生儿167例,TRUST阳性31例,ELISA阳性157例,TRUST与ELISA均为阳性为31例,梅毒阳性率为0.195%(31/15 893);胎传梅毒阳性率为18.56%(31/167)。通过青霉素治疗,31例患病新生儿治愈20例,治愈率为64.52%,好转10例,比例为32.26%,死亡1例,死亡率3.23%。结论秦皇岛地区新生儿梅毒感染率达到0.20%,梅毒阳性产妇的新生儿的梅毒感染率达到18.56%。青霉素治疗梅毒感染的新生儿,治愈率较高,但部分对青霉素过敏的患儿应选择其它替代药物治疗。
Objective To investigate neonatal syphilis infection and prognosis in Qinhuangdao area. Methods A total of 15 893 newborns delivered in Qinhuangdao Maternal and Child Health Hospital from May 2013 to May 2015 were enrolled in this study. TRUST and ELISA were used to detect neonatal syphilis infection. According to the situation of children with intravenous infusion of penicillin or procaine or ceftriaxone (non-penicillin) or ampicillin treatment of children, to observe the clinical treatment. Results Among the 15 893 mothers, 167 were positive for syphilis antibody (1.05%); 167 were newborn with 167 syphilis antibody positive mothers, 31 were TRUST positive, 157 were ELISA positive, and 31 were TRUST and ELISA , The positive rate of syphilis was 0.195% (31/15 893); the positive rate of syphilis was 18.56% (31/167). Through penicillin treatment, 31 cases of newborns cured 20 cases, the cure rate was 64.52%, improved in 10 cases, the proportion was 32.26%, 1 died, the mortality rate was 3.23%. Conclusion The neonatal syphilis infection rate in Qinhuangdao reached 0.20%, and the syphilis infection rate in neonates with syphilis was 18.56%. Penicillin treatment of syphilis infection in newborns, the cure rate is higher, but some of the children allergic to penicillin should choose other alternative medicine treatment.