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本文报道了应用改良微量杀弧菌抗体检测方法,检测男性成人霍乱菌苗免疫对象血清181人份,其平均免疫次数5.7次,距末次免疫平均时间198.59天,杀弧菌抗体GMT为959.18,检测未接种者17名,GMT为57.05。经4次以上免疫者,杀弧菌抗体水平较高,免疫4～10次,11～14次和15次以上对象共94名,GMT分别为1,875.86、1,874.13和1,712.77,在这一范围内,抗体水平未随免疫次数增多而升高。只经3次以下免疫,其抗体水平较低,抗体水平同免疫次数有关。110名2～20次免疫对象,每次免疫间隔6个月,在距末次免疫八个月范围内,抗体水平无明显下降,其中距末次免疫60天内(平均37.53天,平均免疫7.19次)32人,GMT为1,272.91;180天以上(平均232.29天,平均免疫8.73次)21人,GMT为1,237.66,这一现象可能因多次免疫而产生。
This article reports the application of improved detection method of antimicrobial antibodies against Vibrio cholerae to detect serum of 181 adult male cholera vaccine recipients, the average number of immunizations 5.7 times, 198.59 days from the last immunization average, antimicrobial antibody GMT was 959.18, detection 17 were unvaccinated, GMT was 57.05. After more than 4 times of immunization, the level of Vibrio cholerae antibody was high, immunized 4 ~ 10 times, 11 ~ 14 times and 15 times more than 94 objects, GMT were 1,875.86,1,874.13 and 1,712.77 respectively. Within this range, The level did not increase with the number of immunizations. Only less than 3 immunizations, the antibody level is low, the antibody level with the number of immunizations. 110 immunized subjects from 2 to 20 times each immunization interval of 6 months, within eight months from the last immunization no significant decrease in antibody levels, which within 60 days from the last immunization (an average of 37.53 days, the average immune 7.19 times) 32 Person, with a GMT of 1,272.91. For more than 180 days (mean 232.29 days, with an average of 8.73 immunizations), 21 people had a GMT of 1,237.66. This phenomenon may be caused by multiple immunizations.