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目的评价长方案IVF-ET过程中出现慢反应的患者使用尿源性高纯卵泡刺激素(HP-FSH)的临床结局。方法回顾性分析行长方案降调节后对卵泡刺激素(FSH)呈慢反应的患者687例,根据所使用药物的不同分为A组(重组FSH组)373例和B组(重组FSH联合尿源性FSH组)314例,比较两组患者的基础状态、临床指标及助孕结局。结果 A组患者促性腺激素(Gn)天数、Gn总量、FSH总量均低于B组,Gn费用、获卵数及因卵巢过度刺激综合征(OHSS)全胚冻存率高于B组,差异均有统计学意义(P<0.05);两组的FSH启动剂量、HMG总量、LH水平、移植胚胎数、可利用胚胎数比较差异均无统计学意义(P>0.05);两组的胚胎种植率、临床妊娠率、早期流产率差异均无统计学意义(P>0.05)。结论对于卵巢储备功能正常的慢反应患者,使用尿源性高纯FSH可以获得与重组FSH相似妊娠结局并降低促排卵药物的费用和OHSS的发生率。
Objective To evaluate the clinical outcomes of patients with slow-response urinary high-purity follicle-stimulating hormone (HP-FSH) who have experienced slow-response IVF-ET regimens. Methods A retrospective analysis of regulators in the regulators of the regulators of follicle stimulating hormone (FSH) after a slow response in 687 patients, according to the use of drugs are divided into group A (recombinant FSH group) 373 cases and group B (recombinant FSH combined urine Source FSH group) 314 cases, the basic status of the two groups were compared, clinical indicators and pregnancy outcomes. Results The numbers of gonadotrophin (Gn), total Gn and total FSH in group A were lower than those in group B, the cost of Gn, the number of oocytes retrieved and the rate of whole embryo cryopreservation due to ovarian hyperstimulation syndrome (OHSS) were higher than those in group B (P <0.05). There was no significant difference in the number of FSH priming dose, the total amount of HMG, the level of LH, the number of embryos transferred and the number of embryos available in both groups (P> 0.05) There was no significant difference in embryo implantation rate, clinical pregnancy rate and early miscarriage rate (P> 0.05). Conclusion For patients with slow response to normal ovarian reserve, the use of high-purity urine-derived FSH can achieve similar pregnancy outcomes as recombinant FSH and reduce the cost of ovulation induction drugs and OHSS.