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目的：了解增殖细胞核抗原（ＰＣＮＡ）与膀胱肿瘤的病理分级、复发的关系。方法：选择５０例有随访结果的膀胱移行细胞癌石蜡病理切片采用免疫组化Ｓ－Ｐ法进行ＰＣＮＡ检测。结果：ＰＣＮＡ表达与膀胱移形细胞癌的病理分级关系显著（Ｐ≤０．０５），ＰＣＮＡ增殖指数随肿瘤病理分级的升高而增高。结论：复发肿瘤中ＰＣＮＡ高表达为肿瘤恶化的一个客观指标；ＰＣＮＡ表达对肿瘤演变、术后随访及治疗有一定的指导意义，是判断膀胱移行细胞癌恶性程度和预后的一个重要标记。
Objective: To investigate the relationship between proliferating cell nuclear antigen (PCNA) and pathological grade and recurrence of bladder tumor. Methods: Fifty cases of bladder transitional cell carcinoma paraffin sections were selected for immunohistochemical S-P staining. Results: The expression of PCNA was significantly correlated with the pathological grade of bladder transitional cell carcinoma (P≤0.05). The proliferation index of PCNA increased with the increase of tumor grade. Conclusion: The high expression of PCNA in recurrent tumors is an objective indicator of tumor progression. The expression of PCNA may be a guide for tumor progression, follow-up and treatment. It is an important marker for judging the malignant degree and prognosis of BTCC.