大多数泌尿科医师认识到膀胱内化疗作为预防肿瘤复发的重要性。常规的膀胱内化疗需要反复插导尿管以灌注细胞毒剂,不少病人有化学性膀胱炎的激惹症状。为了避免细胞毒性药物的不良影响而在寻找一种口服的从尿排泄达到有效的化学预防。考虑到氨甲喋呤是适合的药剂,由于小剂量能成功地从胃部吸收。虽然部分被肝代谢并和血浆蛋白结合而大部未经改变从尿排出。根据这药物动力学与正常尿排泄的型 Most urologists recognize the importance of intravesical chemotherapy as a prevention of tumor recurrence. Conventional intravesical chemotherapy requires repeated catheterization to perfuse cytotoxic agents, and many patients have irritating symptoms of chemical cystitis. In order to avoid the adverse effects of cytotoxic drugs in the search for an oral effective from the urinary excretion of chemical prevention. Given that methotrexate is a suitable agent, it can be successfully absorbed from the stomach due to the low dose. Although partially metabolized by the liver and bound to plasma proteins, most of it is excreted from the urine without any change. According to this pharmacokinetic model with normal urinary excretion