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甲氨蝶呤治疗克隆病糖皮质激素能有效地改善克隆病（Ｃｒｏｈｎ＇ｓｄｉｓ－ｅａｓｅ）的症状，但毒性很大。笔音参照前人经验设计一个多中心随机双盲安慰剂对照研究（１９９２～１９９４）以观察甲氨蝶呤治疗慢性活动性克隆病的效能。１４１例泼尼松治疗至少３个月以上未...
Methotrexate treatment Clonopathy Glucocorticoids can effectively improve the symptoms of Crohn’s Dis-ease, but the toxicity is great. According to the experience of our forefathers, we designed a multicenter randomized double-blind placebo-controlled study (1992-1994) to observe the efficacy of methotrexate in the treatment of chronic active Crohn’s disease. 141 cases of prednisone for at least 3 months or more ...