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绒癌患者的处理已引向化疗,对有广泛转移者,单种药物的疗效不如联合化疗。为了提高存活率,已经提出并试用了几种细胞毒药物联合使用的方案。有时疗效不肯定,但联合给药的毒性严重,用于联合化疗中的一些药物,在单独使用时并未证实对妊娠滋养叶疾患有效。争光霉素(Bleomycin)是一种对骨髓抑制较轻的细胞毒药物,在控制淋巴瘤、鳞癌、睾丸肿瘤中有效。有报告说35%的睾丸绒癌患者对单一争光霉素化疗有效,75%对争光霉素联合长春新碱化疗有反应。作者对5例40岁以下,患恶性滋养叶疾患(或局限于子宫或有盆腔及肺转移)的女性患者进行观察。从罹病到出现症状的时间少于4个月,最初尿HCG浓度低于10万国际单位/24小时。以生化测定
Treatment of choriocarcinoma has led to chemotherapy, for those with extensive metastases, the efficacy of a single drug as combined with chemotherapy. In order to improve the survival rate, several cytotoxic drugs have been proposed and tested in combination. Sometimes the curative effect is not certain, but the combined toxicity is serious. Some drugs used in combination chemotherapy have not been proved to be effective in gestational trophoblastic diseases when used alone. Bleomycin is a cytotoxic drug that inhibits myelosuppression and is effective in the control of lymphoma, squamous cell carcinoma and testicular tumors. It has been reported that 35% of testicular choriocarcinoma patients with a single bleomycin chemotherapy, 75% of bleomycin with vincristine chemotherapy. The authors looked at five women under the age of 40 who had a malignant trophoblastic disorder (either limited to the uterus or pelvic and lung metastases). Symptoms from illness to symptoms occur in less than 4 months, with initial urinary HCG concentrations below 100,000 international units / 24 hours. To biochemical determination