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Clarke等认为滋养叶“剩余”物质可在流产后残留,后分娩的儿童可有无脑儿或脊柱裂(AS-B),推测剩余物质可干扰胎儿早期生存时神经管的正常形成。此种见解后被Gardiner等证实。作者对此作了探讨。收集1965～1976年间所有产妇,探讨ASB与流产史、社会阶级、母亲年龄和经产情况间关系。共69,056例母亲分娩了70,781例婴儿。其中331例为ASB(146例无脑儿,185例脊柱裂),总发生率为4.7/1,000产儿。在321例ASB婴儿中,248例
Clarke et al. Argue that “excess” nourishment leaves may remain after abortion, and children with postpartum birth may have cerebral or spina bifida (AS-B), presumably remaining substances may interfere with normal neural tube formation during early fetal survival. This opinion was confirmed by Gardiner et al. The author discusses this. All mothers from 1965 to 1976 were collected to investigate the association of ASB with history of abortion, social class, mother’s age, and by-product status. A total of 69,056 mothers gave birth to 70,781 infants. Of these, 331 were ASB (146 children without a brain, 185 spina bifida) with a total incidence of 4.7 / 1,000 births. In 321 ASB infants, 248 cases