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胃胃排空目前,很少有关人类胃排空受年龄影响的资料。1975年Webster等通过钡餐检查发现18～35岁组与63～95岁组胃排空钡的时间无差异。1981年Evans等以含~(99m)Tc-二乙三胺五乙酸(DTPA)的流质试餐作腹部闪烁扫描,发现老年组(平均77岁)胃排空半量~(99m)Tc-DTPA需123min,而年轻组(平均26岁)为47min。但Kramer等用同样方法观察了4例67～75岁的老人,其胃排空时间正常。虽然胃排空时间有随年龄增长而延长的可能,但迄今仍未能证实。老年人胃排空延长时,有可能导致消化不良,而且从理论上说,有可能延缓药物的生物利用率和导致药物的最高血清浓度
Gastric emptying At present, there is very little information on the age-dependent effects of human gastric emptying. In 1975, Webster and other barium meal examination found that 18 to 35 years old group and 63 to 95 years old gastric emptying of barium was no difference in time. In 1981, Evans and other liquid samples containing 99mTc-diethylenetriaminepentaacetic acid (DTPA) scintigraphy scans, found that the elderly group (mean 77 years) gastric emptying ~ (99m) Tc-DTPA required 123 min, while the younger group (mean 26 years) was 47 min. However, Kramer et al used the same method to observe the four elderly 67-75 years old with normal gastric emptying time. Although gastric emptying may increase with age, it has so far not been confirmed. Elderly gastric emptying may lead to indigestion, and in theory, it is possible to delay the bioavailability of the drug and lead to the highest serum concentration of the drug