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目的：评价加速超分割放射治疗食管癌的疗效。方法：食管鳞癌９８例随机分为常规组和加速超分割组。常规组：１８０～２００ｃＧｙ／次，５次／周，总量６０００～７０００ｃＧｙ／６～７周；加速超分割组：１５０ｃＧｙ／次，２次／日，间隔６小时，总量５４００ｃＧｙ／３５周。两组病人均采用６０Ｃｏ远距离外照射。结果：常规组１，３，５年生存率分别为４６％（２３／５０）、２０％（１０／５０）、１２％（６／５０）；加速超分割组１，３，５年生存率分别为７０８％（３４／４８）、３９６％（１９／４８）、２９２％（１４／４８），加速超分割组明显优于常规组（Ｐ＜００５），而两组放疗反应和并发症无明显差异。结论：加速超分割放疗能明显提高食管癌病人的生存率，但不增加放疗反应及并发症。
Objective: To evaluate the efficacy of accelerated hyperfractionation radiotherapy for esophageal cancer. Methods: 98 cases of esophageal squamous cell carcinoma were randomly divided into conventional group and accelerated hyperfractionation group. The routine group: 180 ~ 200cGy / time, 5 times / week, the total amount of 6000 ~ 7000cGy / 6 ~ 7 weeks; accelerated hyperfractionation group: 150cGy / time, 2 times / day, 6 hours apart, the total 5400cGy / 3 5 week. Two groups of patients were used 60Co long-range exposure. Results: The 1, 3, 5-year survival rates were 46% (23/50), 20% (10/50) and 12% (6/50) in the conventional group respectively. The 1-, 3-, 5- year survival rates (34/48), 396% (19/48), 292% (14/48), respectively. The accelerated hyperfractionation group was significantly better than the conventional group (P <005) There was no significant difference between the two groups in radiotherapy response and complications. Conclusion: Accelerated hyperfraction radiotherapy can significantly improve the survival rate of esophageal cancer patients, but does not increase the radiotherapy response and complications.