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本实验对消炎痛双层栓和普通栓的家兔体内生物利用度进行了研究。结果表明:消炎痛双层栓的AUC_(0_5)明显高于普通栓(P<0.01)。双层栓可作为提高栓剂生物利用度的一种有效形式。
In this experiment, the bioavailability of indomethacin double plug and ordinary plug rabbits in vivo were studied. The results showed that the AUC_ (0_5) of indomethacin double-layer suppository was significantly higher than that of the common suppository (P <0.01). Double-layered suppository can be used as an effective form of improving the bioavailability of suppositories.