实体癌化疗开始于第一次世界大战中用氮芥治疗恶性淋巴瘤,以后又通过多药物进行动物模型筛迭,发现初步疗效后,在各种癌患者身上试用而获得的。所以,新抗癌药的发现非常缓慢。给药方法方面,一直是单药连续应用直至失效或出现毒性,而 Solid cancer chemotherapy began with the use of nitrogen mustard in the treatment of malignant lymphoma in World War I, and was later screened through multi-drug animal models. After initial efficacy was discovered, it was tried on various cancer patients. Therefore, the discovery of new anticancer drugs is very slow. The method of administration has always been single-agent continuous application until failure or toxicity.