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目的 通过了解婴儿胎传抗体衰减情况和不同月龄婴儿对麻疹疫苗的免疫应答情况 ,探讨减少小月龄麻疹病例的对策。方法 采用ELESA方法测定血清中麻疹IgG抗体水平。结果 通过对胎传抗体追踪观察发现 ,新生儿抗体水平不高 ,3月龄时降低 5 0 % ,6月龄和 8月龄降到 15 %左右 ,几乎无保护作用 ,且 6月龄和 8月龄婴儿接种疫苗后免疫成功率间无差别。结论 目前新生儿麻疹抗体水平低 ,到 6月龄时大部分婴儿胎传抗体已降到保护水平以下。因此 ,为实现消灭麻疹的总目标 ,在小月龄麻疹发病率高的地区可考虑将麻疹初免月龄从8月龄提前到 6月时进行
OBJECTIVE: To understand the attenuation of infant’s fetal transmission antibody and the immune response to measles vaccine in infants of different ages, and to explore the strategies to reduce the incidence of measles. Methods ELESA method was used to determine the level of measles IgG antibody in serum. Results The follow-up observation of fetal antibody showed that neonatal antibody level was not high, decreased 50% at 3 months of age, decreased to about 15% at 6 months and 8 months of age with almost no protective effect, and 6 months of age and 8 There was no difference in the success rate of immunization among months old babies after vaccination. Conclusions At present, the level of neonatal measles antibody is low, and most of the babies’ fetal antibodies have dropped below the level of protection by the age of 6 months. Therefore, in order to achieve the general goal of eradicating measles, it may be considered that the first month of measles measles should be advanced from the age of 8 months to the end of June in areas where the incidence of measles in small months is high