１９５例男女性不育症患者经专科门诊临床检查，辅以精液分析、内分泌测定、Ｂ超等筛选后，进行细胞遗传学分析。结果显示：染色体异常者６１例，占３１．２８％（６１／１９５）。其中以克氏征和杜纳氏征占绝大多数，为６２．２９％（３８／６１），其他病人则显示常染色体异常。另外，９号染色体臂间倒位及形态的多态性亦与不育有关。本文提示：对男女性不育症患者有生殖器发育异常或原因不明者，均应作染色体检查。 195 cases of male and female infertility patients by clinical specialist clinics, supplemented by semen analysis, endocrine tests, B-screening, etc., for cytogenetic analysis. The results showed that: 61 cases of chromosomal abnormalities, accounting for 31.28% (61/195). Among them, the majority of Keshi’s sign and Duna’s sign were 62.29% (38/61), while other patients showed autosomal abnormalities. In addition, chromosome 9 inversions and morphological polymorphisms are also related to infertility. This article suggests that: male or female genital infertility patients with genital abnormalities or unexplained, should be made for chromosomal examination.