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目的:对比克拉霉素与阿莫西林分别联合奥美拉唑及甲硝唑治疗小儿消化性溃疡的临床疗效差异。方法:选取前来我院儿科就诊的300例患儿平均分为观察组和对照组,观察组给予克拉霉素联合奥美拉唑及甲硝唑进行治疗,对照组给予阿莫西林联合奥美拉唑及甲硝唑进行治疗,治疗周期为5周。结果:两组患儿溃疡愈合率差异不显著(P>0.05),HP清除率观察组患儿显著高于对照组(P<0.05),观察组患儿不良发应发生率显著低于对照组患儿(P<0.05)。结论:克拉霉素联合奥美拉唑及甲硝唑在HP根除率及不良发应发生率上显著高于阿莫西林三联疗法,是较为理想的方案。
Objective: To compare the clinical efficacy of clarithromycin and amoxicillin in combination with omeprazole and metronidazole in children with peptic ulcer. Methods: A total of 300 children who came to our hospital for pediatric treatment were divided equally into observation group and control group. The observation group was treated with clarithromycin combined with omeprazole and metronidazole. The control group was given amoxicillin combined with Ogilvy & Mather Lazole and metronidazole for treatment, the treatment cycle of 5 weeks. Results: There was no significant difference in the healing rate between the two groups (P> 0.05). The children with HP clearance rate in the observation group were significantly higher than those in the control group (P <0.05). The incidence of bad hair in the observation group was significantly lower than that in the control group Children (P <0.05). Conclusion: Clarithromycin combined with omeprazole and metronidazole in the HP eradication rate and incidence of adverse reactions was significantly higher than amoxicillin triple therapy, is an ideal solution.