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目的:对比高剂量和低剂量克拉霉素联合奥美拉唑、羟氨苄青霉素、甲硝唑四联疗法治疗小儿消化性溃疡的治疗效果。方法:选择260例患有消化性溃疡的患儿,平均分为高剂量组和低剂量组,分别使用大小两种剂量的克拉霉素与其他三种药物联合治疗小儿消化性溃疡,对比治疗效果。结果:两组患儿接受治疗后3天以及1周时腹痛的缓解情况与治疗前进行对比均差异显著(P<0.05)。低剂量组患儿幽门螺旋杆菌抗体检测阳性率以及不良反应率都显著低于高剂量组(P<0.05)。结论:使用小剂量克拉霉素对小儿消化性溃疡进行治疗,治疗效果显著。
Objective: To compare the therapeutic effects of high dose and low dose clarithromycin combined with omeprazole, amoxicillin and metronidazole quadruple therapy on children with peptic ulcer. Methods: A total of 260 children with peptic ulcer were selected and equally divided into high dose group and low dose group. Clarithromycin was administered to children with peptic ulcer separately with two doses of the same dosage. The therapeutic effect was compared with that of the other three drugs . Results: There was a significant difference between the two groups in the treatment of abdominal pain at 3 days and 1 week after treatment (P <0.05). The detection rate of Helicobacter pylori antibody and the rate of adverse reactions in the low-dose group were significantly lower than those in the high-dose group (P <0.05). Conclusion: The use of small doses of clarithromycin in children with peptic ulcer treatment, the treatment effect is remarkable.