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目的 探讨乌司他汀对心肺复苏后急性脑缺血 再灌注损伤的保护作用。方法 2 1例病人随机分为治疗组 ( 11例 )和对照组 ( 10例 ) ,治疗组在治疗过程中静注乌司他汀 10万U ,心肺复苏成功后每日静滴乌司他汀 2 0万U～ 60万U。对照组不用乌司他汀 ,余治疗措施同治疗组。定时观察记录两组血压、心率、呼吸以及神志变化 ,以Glasgow昏迷量表判断疗效。结果 治疗组有效率 63 .7% ,对照组 2 0 % ,比较有显著性差异 ,P值 <0 .0 5。结论 乌司他汀对心肺复苏后急性脑缺血 再灌注损伤有一定的保护作用。
Objective To investigate the protective effect of ulinastatin on acute cerebral ischemia-reperfusion injury after cardiopulmonary resuscitation. Methods 21 patients were randomly divided into treatment group (n = 11) and control group (n = 10). The treatment group was treated with ulinastatin (UU) at the dose of 100,000 U per day. After the success of CPR, Ulinastatin Million U ~ 600,000 U. The control group without ulinastatin, more than the same treatment treatment group. Timed observation recorded two groups of blood pressure, heart rate, respiration and changes in consciousness, with Glasgow coma scale to determine the efficacy. Results The effective rate was 63.7% in the treatment group and 20% in the control group, with significant difference (P <0.05). Conclusion Ulinastatin has a protective effect on acute cerebral ischemia-reperfusion injury after cardiopulmonary resuscitation.