国外报导,长期应用醋氮酰胺可产生酸中毒,但一般认为程度较轻,可以代偿。我院发现3例醋氮酰胺引起严重的代谢性酸中毒,一例为独肾病人,服用一般治疗量,引起严重代谢性中毒,文献上未见记载。特报告如下。例1 杨××男8岁右眼被石子击伤,视力障碍4天,诊断为前房出血,继发性青光眼,1976年6月28日入院。入院后,口服云南白药0.2g,每日3次,透明质酸酶1500单位肌注,每日1次,醋氮酰胺250mg,每日3次。次日,眼压未被控制,仍恶心呕吐,将醋氮酰胺改为每日4次。7月 Foreign reports, long-term use of acetic acid amide can produce acidosis, but generally considered to be a lesser extent, can be compensated. In our hospital, 3 cases of acetic acid amide caused serious metabolic acidosis, one case of kidney disease patients, taking the general treatment, causing severe metabolic poisoning, the literature has not been documented. Special report is as follows. Example 1 Yang × × male 8-year-old right eye injured by stones, visual impairment for 4 days, diagnosed as anterior chamber bleeding, secondary glaucoma, June 28, 1976 admission. After admission, oral Yunnanbaiyao 0.2g, 3 times a day, 1500 units of hyaluronidase intramuscularly, 1 day, vinegar azamide 250mg, 3 times a day. The next day, intraocular pressure was not controlled, nausea and vomiting, the vinegar amide to 4 times a day. July