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纳洛酮(Naloxone,NLX)又名烯丙羟吗啡酮,是吗啡样物质的特异拮抗剂。纳洛酮与吗啡受体的亲和力比吗啡和β-内啡肽大,能竞争性阻止并取代吗啡样物质与受体结合,从而阻断吗啡样物质的作用,对调节感知与运动、睡眠与觉醒、心血管功能和呼吸运动等。起着神经递质和调节作用。随着近年来对NLX的深入研究,使其在临床上的应用越来越广泛,现结合文献将其在神经系统疾病中的临床应用进展情况综述如下。
Naloxone (NLX), also known as aloxymorphone, is a specific antagonist of morphine-like substances. Naloxone, which has a greater affinity for morphine than morphine and beta-endorphin, competitively blocks and replaces the morphine-like substance that binds to the receptor, blocking the effects of morphine-like substances and regulating cognition and exercise, sleep and Awakening, cardiovascular function and respiratory exercise. Plays a neurotransmitter and regulatory role. With the in-depth study of NLX in recent years, its clinical application is more and more widely. The progress of its clinical application in nervous system diseases is summarized in the following literature.