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目的探讨慢性肾功能衰竭（ＣＲＦ）患者预防性抗结核治疗的价值。方法对实验组中具有并发结核危险因素的ＣＲＦ患者进行预防性抗结核治疗，历史对照组中具有同样危险因素者未作任何处理。结果实验组在观察期间活动性结核的发生率（０．７６％、２／２６１）明显低于对照组（４．７０％、３９／８３０）。按预防性治疗前病人具有的危险因素分层进行比较表明，血清抗ＰＰＤ－ＩｇＧ阳性的ＣＲＦ病人，接受预防性治疗者活动性结核的发生率明显低于未接受预防性治疗者。结论对具有危险因素的ＣＲＦ病人实施预防性抗结核治疗有助于降低这类病人活动性结核的发生率
Objective To investigate the value of prophylactic anti-TB therapy in patients with chronic renal failure (CRF). Methods The patients with CRF in the experimental group who had risk factors for concurrent TB were treated with prophylactic antituberculous therapy, while those with the same risk factors in the historical control group were given no treatment. Results The incidence of active tuberculosis (0.76%, 2/261) in the experimental group during the observation period was significantly lower than that in the control group (4.70%, 39/830). A stratified comparison of pre-treatment risk factors showed that the incidence of active tuberculosis among patients who received anti-PPD-IgG seropositivity for active prevention of tuberculosis was significantly lower than those who did not receive prophylactic treatment. Conclusions Prophylactic antituberculosis treatment of CRF patients with risk factors may help reduce the incidence of active tuberculosis in these patients