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目的：比较培哚普利与卡托普利对老年原发性高血压的降压效应与安全性。方法：６０例老年原发性高血压患者随机分组接受培哚普利（４～８ｍｇ／ｄ）和卡托普利（３７．５～７５．０ｍｇ／ｄ）（各３０例）治疗４周。结果：培哚普利和卡托普利的降压总有效率偶测血压分别为９０．０％和８６．７％（Ｐ＞０．０５），动态血压监测分别为９５．０％和６５．０％（Ｐ＜０．０５）。结论：培哚普利治疗老年原发性高血压有效而安全，降低夜间舒张压优于卡托普利。
Objective: To compare the antihypertensive effects and safety of perindopril and captopril in the elderly with essential hypertension. Methods Sixty elderly essential hypertension patients were randomized to receive perindopril (4-8 mg / d) and captopril (37.5-75.0 mg / d) (n = 30 each) for 4 weeks. Results: The total effective blood pressure of perindopril and captopril were 90.0% and 86.7%, respectively (P> 0.05). Ambulatory blood pressure monitoring was 95.0% and 65 respectively. 0% (P <0.05). CONCLUSION: Perindopril is effective and safe in the treatment of senile essential hypertension and is superior to captopril in reducing nocturnal diastolic pressure.