肾性骨营养不良是指慢性肾功能衰竭(肾衰)所并发的骨病,包括纤维性骨炎、骨软化、骨质疏松、骨硬化及软组织钙化等。经骨活检证实,凡作透析的肾衰患者凡乎都有骨组织学异常。Roux 等报告来自3个不同透析中心的103例慢性肾衰患者中,101例呈现骨组织形态学异常,其中以纤维性骨炎(68%)、骨软化(40.7%)及骨质疏松(50.2%)为最常见;且半数以上骨组织学异常为复合性病变。发病机制与继发于肾衰的内分泌紊乱如甲状旁腺素、降钙素及维生素 D 分泌及代谢的改变有关,尚与代谢产物如中分子物质、磷和重金属等的积蓄和透析对机体及骨代谢的直接影响有关。近10余年来随着透析治疗的普及、尿毒症患者寿命的延长和维生素 D 代谢研究的深入,对本病的研究随之深入,其发病率有所增 Renal osteodystrophy refers to bone disease complicated by chronic renal failure (renal failure), including fibrous osteitis, osteomalacia, osteoporosis, osteosclerosis, and soft tissue calcification. Biopsy confirmed that all dialysis patients with renal failure who have almost all abnormal bone histology. Of the 103 patients with chronic renal failure reported by three different dialysis centers, Roux et al reported 101 cases of abnormalities in bone morphology, including fibrous osteitis (68%), osteomalacia (40.7%) and osteoporosis %) Is the most common; and more than half of the bone histological abnormalities as complex lesions. Pathogenesis and secondary to renal failure, endocrine disorders such as parathyroid hormone, calcitonin and vitamin D secretion and metabolic changes, but also with metabolic products such as molecular substances, phosphorus and heavy metals such as savings and dialysis on the body and Bone metabolism is directly related to the impact. Over the past 10 years with the popularity of dialysis treatment, uremia patients with prolonged life expectancy and vitamin D metabolism in-depth study of the disease followed, the incidence has increased