通过在大鼠整个怀孕期间苯醋酸钠灌胃，以观察苯醋酸（PA）对胎鼠和成熟大鼠中枢神经系统的损害情况。从而证实患苯丙酮尿病（PKU）母亲体内过多的PA是造成所产非PKU胎鼠中枢神经异常的发病原因。而脑胶质瘤细胞是和胎脑中枢神经细胞高度相似的肿瘤神经细胞，由此推测PA可能是一种对脑胶质瘤细胞有高度选择性毒性作用的化合物。 Phenylacetate (PA) was used to observe the damage to the central nervous system of fetal rats and mature rats by intragastric administration of sodium acetate throughout the pregnancy of the rats. Confirming that excessive PA in a mother suffering from phenylketonuria (PKU) is responsible for the onset of central nervous abnormalities in non-PKU fetal rats. The glioma cells and fetal brain central nerve cells are highly similar to the tumor cells, suggesting that PA may be a highly selective cytotoxic compounds of glioma cells.