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目的 :评价丙戊酸钠缓释片治疗儿童癫痫的疗效及稳态期血药浓度。方法 :30例患各种类型癫痫的儿童 (男性 2 2例 ,女性 8例 ;年龄 8.2±s 2 .4a)服丙戊酸钠缓释片 ,剂量为 2 3.8± 2 .9mg/(kg·d) ,qn。治疗d 10 ,服药后 12h和 2 4h(下次服药前 )采血标本 ,用TDx方法测定血清丙戊酸浓度。疗效随访期为 11± 3mo。结果 :稳态期 ,服药后 12h和 2 4h血丙戊酸浓度分别为 10 5± 16mg/L及 68± 13mg/L ,波动指数 (FI)为 0 .4 1。发作控制率为77% ,显效率为 2 0 % ,无明显不良反应。结论 :丙戊酸钠缓释片每日服用 1次治疗儿童癫痫是有效的
Objective: To evaluate the efficacy and steady-state plasma concentration of sodium valproate sustained-release tablets in children with epilepsy. Methods: Thirty children with various types of epilepsy (22 males and 8 females; age 8.2 ± s 2 .4 a) were given sodium valproate sustained-release tablets in a dose of 2 3.8 ± 2 .9 mg / (kg · d), qn. Serum valproic acid concentrations were determined using the TDx method for the treatment of d 10, 12 h and 12 h (before the next dose) of the blood samples. Follow-up effect of 11 ± 3mo. Results: At steady state, the concentrations of blood valproic acid at 12 and 24 h were 105 ± 16 mg / L and 68 ± 13 mg / L, respectively. The fluctuation index (FI) was 0.41. Seizure control rate was 77%, markedly efficient 20%, no significant adverse reactions. Conclusion: Sodium valproate sustained-release tablets taken once daily to treat children with epilepsy is effective