论文部分内容阅读
切除３月龄ＳＤ大鼠双侧卵巢１２周后，其骨形成的参数值明显增加（％Ｌ．Ｐｍ＋５８％，ＢＦＲ／ＢＶ＋１０５％，ＢＦＲ／ＢＳ＋７４％，％０．Ｐｍ＋１８８％），同时骨吸收的参数值增加（％Ｅｒ．Ｐｍ＋１５５％），荧光标记周长与吸收周长的比率－４１％，由于骨吸收大于骨形成，骨质丢失（％Ｔｂ．Ａｒ－５９％，Ｔｂ．Ｔｈ一１４％），出现高转换型骨质疏松。分别用蛇床子素（ｏｓｔｈｏｌｅ）６．７ｍｇ·ｋｇ￣（－１）ｉｇ，每周６次，尼尔雌醇（ｎｉｌｅｓｔｒｉｏｌ）１ｍｇ·ｋｇ￣（－１）ｉｇ，每周１次，持续１２周，均能明显抑制去卵巢诱导的骨高转换，防止骨质丢失。但蛇床子素抑制骨高转换的效应比尼尔雌醇低（蛇床子素治疗组比尼尔雌醇治疗组％Ｔｂ．Ａｒ一５５％）。
After excision of the bilateral ovaries of SD rats at 3 months of age, the parameters of bone formation were significantly increased (%L.Pm+58%, BFR/BV+105%, BFR/BS+74%, %0.Pm+188%), and bone resorption The parameter value increases (%Er.Pm+155%), the ratio of fluorescent marker perimeter to absorption perimeter -41%, due to bone resorption greater than bone formation, bone loss (%Tb.Ar-59%, Tb.Th-14% ), high conversion osteoporosis. Osthole 6.7 mg·kg ̄(-1) ig, 6 times per week, nilestriol 1 mg·kg ̄(-1) ig once weekly for 12 weeks Both can significantly inhibit ovariectomy-induced bone hyperversion and prevent bone loss. However, the effect of osthole on inhibiting bone turnover was lower than that of nilestriol (5% of Tb.Ar in the osthole-treated group vs. Nilestriol-treated group).