论文部分内容阅读
目的比较3种不同给药方案在早孕药物流产中的临床效果。方法收集早孕患者375例的临床资料,将患者随机分为3组,A组患者单纯服用米非司酮+米索前列醇,B组患者服用米非司酮+米索前列醇+甲氨蝶呤,C组患者服用米非司酮+米索前列醇+达那唑。比较3组患者的临床效果。结果 A组患者完全流产109例(87.2%),不完全流产11例(8.8%),流产失败5例(4.0%);B组患者完全流产123例(98.4%),不完全流产2例(1.6%),流产失败0例(0.0%);C组患者完全流产121例(96.8%),不完全流产3例(2.4%),流产失败2例(1.6%);B、C组患者完全流产率与A组比较,差异均有统计学意义(均P<0.05);B组患者的子宫出血量明显减少,阴道出血时间、孕囊排出时间明显短于C组患者,差异均有统计学意义(均P<0.05)。结论甲氨蝶呤、达那唑辅助米非司酮配伍米索前列醇能明显提高药物流产的成功率,而甲氨蝶呤能较好地改善子宫出血症状,减不良反应的发生。
Objective To compare the clinical effects of three different dosage regimens in medical abortion in early pregnancy. Methods The clinical data of 375 early pregnant women were collected and randomly divided into three groups. Patients in group A were treated with mifepristone plus misoprostol alone. Patients in group B received mifepristone plus misoprostol plus methotrexate The patients in group C took mifepristone plus misoprostol plus danazol. The clinical effects of the three groups were compared. Results In group A, 109 cases (87.2%) of complete abortion, 11 cases (8.8%) of incomplete abortion and 5 cases (4.0%) of abortion failed. In group B, 123 cases (98.4%) of complete abortion, 2 cases of incomplete abortion 1.6%), 0 failed abortion (0.0%); 121 patients (96.8%) were completely aborted in Group C, 3 (2.4%) were incomplete abortion, and 2 The abortion rate was significantly higher than that in group A (all P <0.05). The bleeding volume in group B was significantly decreased, the vaginal bleeding time and gestational sac discharge time were significantly shorter than those in group C, with statistical differences Significance (all P <0.05). Conclusion Methotrexate and danazol can enhance the success rate of medical abortion with the combination of mifepristone and misoprostol, and methotrexate can improve the symptoms of uterine bleeding and reduce the incidence of adverse reactions.