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尾加压素Ⅱ(urotensinⅡ,UⅡ)是20世纪80年代从鱼的脊髓尾部下垂体中分离出来的一种“生长抑素”样环肽[1]。1999年Ames等[2]首次报道,人体内一种孤立的G蛋白偶联受体(G-proteincoupled receptor)GPR14,是UⅡ的特异性受体,主要分布于心血管系统和神经系统。UⅡ与其受体结合后使
UrotensinⅡ (UⅡ) is a somatostatin-like cyclopeptide isolated from the tail pituitary of the fish in the1980s [1]. Ames et al [2] reported for the first time in 1999 that an isolated G-protein coupled receptor (GPR14) in the human body is a specific receptor for UII, which is mainly distributed in the cardiovascular system and the nervous system. U Ⅱ and its receptor after binding