在某些病毒感染的宿主中,T细胞总数会出现短暂的显著升高及异种病毒可激活T细胞的现象。为研究其机制,作者采用DNA前体物溴脱氧尿嘧啶(BrdU)标记方法,定量检测在病毒感染中T细胞的增殖反应以及与其有关的诱导因子。通过喂饮含BrdU的水,BrdU可逐渐标记小鼠脾脏及结合淋巴中的CD4~+和CD8~+细胞(BrdU~+)。正常成年去胸腺小鼠 In some virus-infected hosts, there is a transient, significant increase in the total number of T cells and the phenomenon that heterologous viruses can activate T cells. To investigate its mechanism, the authors used a bromodeoxyuridine (BrdU) labeling method to quantitatively detect the proliferative response of T cells and the related induction factors in virus infection. By feeding BrdU-containing water, BrdU could gradually mark the CD4 ~ + and CD8 ~ + cells (BrdU ~ +) in the spleens and lymphocytes of mice. Normal adult thymus mice