本文观察大鼠离体循环肺灌流时血管紧张素转化酶(ACE)活性与心钠素(ANP)含量变化的关系。结果表明Captopril治疗组ACE活性较对照组明显降低(P<0.001),ANP含量则显著增加(P<0.001),并且随着灌流时间的延长ANP含量明显增加(P<0.05),其增加程度与ACE活性负相关(r=-0.725,P<0.01)。以上首次提示ACE可能具有降解ANP的活性,作者推测ACE对ANP与肾素-血管紧张素—醛固酮系统(RAAS)具有双向调节作用。心肾疾患等病理过程中则可能是增恶因子。 This study was designed to investigate the relationship between angiotensin converting enzyme (ACE) activity and the content of atrial natriuretic peptide (ANP) in isolated rat perfused circulation. The results showed that the activity of ACE in captopril treatment group was significantly lower than that in control group (P <0.001), and ANP content was significantly increased (P <0.001), and the content of ANP was significantly increased with the prolongation of perfusion time (P <0.05) ACE activity was negatively correlated (r = -0.725, P <0.01). The above suggests that ACE may be able to degrade ANP activity for the first time. The authors speculate that ACE has bidirectional regulation of ANP and renin-angiotensin-aldosterone system (RAAS). Heart and kidney disease and other pathological processes may be increased by factors.