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本文报告用人眼组织冰冻切片作底物,免疫荧光方法检测了28例内源性葡萄膜炎患者和30例正常人血清抗眼组织抗体,结果表明内源性葡萄膜炎自身抗体的阳性率及抗体效价明显高于正常人(P<0.01),6例急性活动期病人经治疗后自身抗体滴度明显下降。提示自身抗眼组织抗体与内源性葡萄膜炎患者病情活动关系密切,在免疫病理损害上起一定作用。自身抗体检测可作为临床疗效观察的一项指标。
This article reports frozen sections of human eye tissue as substrate, immunofluorescence assay of 28 patients with endogenous uveitis and 30 normal human serum anti-ocular tissue antibodies, the results showed that the positive rate of endogenous uveitis autoantibodies and Antibody titers were significantly higher than those in normal subjects (P <0.01). The titer of autoantibodies was significantly decreased in 6 acute active patients after treatment. Tip anti-ocular tissue antibodies and endogenous uveitis in patients with disease activity is closely related to the immune pathological damage play a role. Autoantibody testing can be used as an indicator of clinical efficacy.