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目的探讨T2DM合并非酒精性脂肪性肝病(NAFLD)血糖波动与非酒精性脂肪性肝病肝纤维化评分(NAFLDFS)的相关性。方法根据NAFLDFS结果将107例T2DM合并NAFLD患者分为肝纤维化低危组(NAFLDFS<0.676)和肝纤维化组(NAFLDFS≥0.676),比较两组间血糖波动等指标,并行Logistic回归分析。结果两组病程、BMI、WC、WHR、HbA1c、HDL-C及平均血糖波动幅度(MAGE)比较差异均有统计学意义(P<0.05或P<0.01)。Logistic回归分析发现,MAGE是NAFLDFS的独立危险因素(OR=2.108,95%CI:1.088~4.085)。结论T2DM合并NAFLD患者MAGE与NAFLDFS独立相关。
Objective To investigate the relationship between non-alcoholic fatty liver disease (T2DM) and non-alcoholic fatty liver disease (NAFLDFS) in T2DM patients with non-alcoholic fatty liver disease (NAFLD). Methods According to the results of NAFLDFS, 107 T2DM patients with NAFLD were divided into low-risk group (NAFLDFS <0.676) and hepatic fibrosis group (NAFLDFS≥0.676). The blood glucose and other indexes were compared between the two groups and Logistic regression analysis was performed. Results The course of disease, BMI, WC, WHR, HbA1c, HDL-C and mean blood glucose fluctuation (MAGE) were significantly different between the two groups (P <0.05 or P <0.01). Logistic regression analysis showed that MAGE was an independent risk factor for NAFLDFS (OR = 2.108, 95% CI: 1.088-4.085). Conclusion MAGE and NAFLDFS are independently associated with T2DM and NAFLD.