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目的 研究眠而康口服液 ( MEKOL)对小鼠的镇静催眠作用 ,并与眠安宁口服液 ( MANOL)和地西泮 (安定 )作比较。方法 动物随机均分为 4组 :生理盐水组 (空白对照 ) ,MEKOL 2个剂量组 ( 11.1、2 2 .2 g· kg- 1 ) ,MANOL 组 ( 4 .0 ml·kg- 1 )。灌胃给药后 ,测定各组药物对阈下剂量戊巴比妥钠小鼠的入睡率 ;催眠剂量戊巴比妥钠小鼠的睡眠时间和催眠剂量戊巴比妥钠小鼠再入睡数及时间 ;测定 MEKOL 2 2 .2、4 4.4 g· kg- 1、安定 2 m g·kg- 1小鼠自主活动次数。统计分析 :t检验法和确切概率检验法。结果 与生理盐水组比较 ,MEKOL能明显增加阈下剂量戊巴比妥钠小鼠的入睡率 ( P<0 .0 5～ 0 .0 0 1) ,延长催眠剂量戊巴比妥钠小鼠的睡眠时间 ( P <0 .0 5～ 0 .0 1) ,使催眠剂量戊巴比妥钠小鼠全部再入睡 ,且入睡时间长于MANOL,并能明显减少小鼠自主活动次数 ( P<0 .0 5～ 0 .0 0 1)。结论 MEKOL 对小鼠具有明显的镇静催眠作用 ,且作用强于MANOL,但稍弱于安定
Objective To investigate the sedative and hypnotic effects of MEKOL on mice and compare it with those of MANOL and Diazepam. Methods Animals were randomly divided into 4 groups: saline group (blank control), MEKOL 2 dose groups (11.1, 22.2 g·kg-1), MANOL group (4.0 ml·kg-1). After intragastric administration, the sleeping rate of the subthreshold dose of pentobarbital sodium was determined for each group of drugs; the sleep time of the hypnotic dose of pentobarbital sodium mice and the number of hypnotic doses of pentobarbital sodium mice reentering the sleep Measure the time of spontaneous activity of MEKOL 22.2,4 4.4 g·kg-1, and stability of 2 mg·kg-1 mice. Statistical analysis: t test and exact probability test. Results Compared with the saline group, MEKOL significantly increased the sleep rate of the subthreshold dose of pentobarbital sodium mice (P<0.05-0.001) and prolonged the hypnotic dose of pentobarbital sodium in mice. Sleep time (P <0. 0 5 ~ 0. 0 1), so that hypnotic doses of sodium pentobarbital mice all fell asleep again, and sleep longer than MANOL, and can significantly reduce the number of times the activity of mice (P <0. 0 5-0. 0 0 1). Conclusion MEKOL has obvious sedative and hypnotic effects on mice, and the effect is stronger than MANOL, but slightly weaker than stability