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目的探讨老年糖尿病并发脑梗死患者载脂蛋白和C反应蛋白的水平变化及其临床意义。方法研究对象为老年糖尿病并发急性脑梗死患者(DACI组)47例,老年非糖尿病性急性脑梗死患者(NDACI组)45例。采用酶法测定其血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A-I(ApoA-I)和载脂蛋白B(ApoB)的水平,散射免疫比浊法测定高敏C反应蛋白(hs-CRP),比较两组间各项指标的差异。结果与NDACI组相比,DACI组患者血清中TC、TG、LDL-C、ApoB水平明显升高(P<0.01),HDL、ApoA-I水平明显降低(P<0.01),hs-CRP水平明显升高(P<0.05)。结论 ApoA-I、ApoB和hs-CRP的水平与脑梗死密切相关,可作为判断糖尿病合并脑血管并发症的高危预测因子。
Objective To investigate the changes of apolipoprotein and C-reactive protein in elderly patients with diabetes mellitus complicated with cerebral infarction and its clinical significance. METHODS: Forty-seven elderly patients with diabetes mellitus (DACI) and 45 elderly non-diabetic patients with acute cerebral infarction (NDACI) were enrolled in this study. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein AI (ApoA-I) And apolipoprotein B (ApoB) were detected by spectrophotometry. The high sensitivity C-reactive protein (hs-CRP) was measured by nephelometry. The differences between the two groups were compared. Results Compared with NDACI group, the serum levels of TC, TG, LDL-C and ApoB were significantly increased (P <0.01), the levels of HDL and ApoA-I were significantly decreased (P <0.01) and the levels of hs-CRP Increased (P <0.05). Conclusions The levels of ApoA-I, ApoB and hs-CRP are closely related to cerebral infarction, which may be used as a high-risk predictor of cerebrovascular complications in diabetic patients.