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为探讨长期心理应激在老年心肌脂质过氧化形成中的作用，观察了为期６周的经多相性应激源（限制、旋转、拥挤）刺激后，青龄鼠（１．５月龄）和老龄鼠（１５月龄）心肌脂质过氧化物（ＬＰＯ）含量和超氧化物歧化酶（ＳＯＤ。谷胱甘肽过氧化酶（ＧＳＨ－ＰＸ）活性的变化，并分析了鼠龄与长期。理应激对以上指标的独立及相互作用。结果显示：与青龄鼠比较，老龄鼠心肌ＬＰＯ含量较高，ＳＯＤ活性较低（Ｐ＜０．０５）；长期心理应激后，老龄鼠。肌ＬＰＯ含量进一步增高，ＳＯＤ活性进一步降低，ＧＳＨ－ＰＸ活性也下降（Ｐ＜０．０５），青龄鼠。肌ＳＯＤ活性增高（Ｐ＜０．０５）；鼠龄与长期。理应激的交互作用对心肌ＬＰＯ含量和ＳＯＤ、ＧＳＨ—ＰＸ活性变化的影响有显著性（Ｐ＜０．０５）、提示外周环境中心理应激源的长期刺激可能促进老年心肌脂质过氧化的形成。
In order to investigate the role of long-term psychological stress in the formation of lipid peroxidation in aged myocardial cells, we observed the effects of long-term psychological stress (restriction, rotation, crowding) (LPO) and superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity in aged rats (15 months old), and the effects of aging and long-term .The results showed that the content of LPO was higher and the activity of SOD was lower in old rats (P <0.05) than that of young rats, and that of aged rats after long-term psychological stress. The LPO content in muscle increased further, SOD activity decreased further, GSH-PX activity decreased (P <0.05), and SOD activity increased in young rats (P <0.05) (P <0.05), which indicated that there was a significant effect on the changes of LPO content and SOD, GSH-PX activity in myocardium The long-term stimulation may promote the formation of senile myocardial lipid oxidation.