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用羟基磷灰石、DEAE－Sephacel和SephacrylS－300纯化了抗急非淋M2型白血病MCAb1D1，纯度为99．9％。用直接交联方法将McAb1D1与HHT仍联，克分子比1：40。该偶合物保持了抗体和药物活性，对急非淋M2型白血病靶细胞有选择性杀伤作用，而对急非淋M1型白血病细胞和Hela细胞无明显杀伤作用。
Anti-ULC M2 leukemia MCAb1D1 was purified with hydroxyapatite, DEAE-Sephacel and Sephacryl S-300 with a purity of 99.9%. McAb1D1 was linked to HHT by direct cross-linking method at a molar ratio of 1:40. The conjugate maintains the antibody and drug activity, selectively killing the acute non-leukemia M2 leukemia target cells, and has no obvious killing effect on the acute non-lymphoid leukemia cells and Hela cells.