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目的:探讨早期溶栓治疗是否改善血管性痴呆的认知能力和蚓激酶制剂溶栓及改善脑梗死后脑功能作用。方法:采用光化学诱导脑梗死大鼠模型,观察假手术组、梗死组、及梗死后治疗组在Ｍｏｒｒｉｓ水迷宫的训练成绩。结果:治疗组较非治疗组学习成绩提高,统计有显著性差异(Ｐ＜０．０１),与假手术组比较无显著性差异。结论:早期蚓激酶治疗脑梗死可改善脑缺血后的认知功能障碍。
Objective: To investigate whether early thrombolytic therapy can improve the cognitive ability of vascular dementia and the activity of lumbrokinase in thrombolytic therapy and improve brain function after cerebral infarction. Methods: The model of cerebral infarction was induced by photochemistry, and the training performance in Morris water maze was observed in sham operation group, infarction group and post-infarction treatment group. Results: Compared with the non-treatment group, the treatment group improved the academic performance, the statistics showed significant difference (P <0.01), and there was no significant difference between the treatment group and the sham operation group. Conclusion: Early lumbrokinase treatment of cerebral infarction can improve the cognitive dysfunction after cerebral ischemia.