根据肿瘤细胞繁殖周期和药物动力学特点，结合临床实践和借鉴国内外治疗经验，我们从1991年至今制定了大剂量程序化疗方案，对16例初发的小儿急性白血病和恶性淋巴瘤进行治疗，本方案省略了颅骨放疗和中间维持治疗，获得较满意疗效，现报道如下。1材料和方法1．1材料13例急性淋 According to the characteristics of tumor cell cycle and pharmacokinetics, combined with clinical practice and reference from the experience of treatment at home and abroad, we have formulated a large dose chemotherapy program since 1991, 16 cases of pediatric acute leukemia and malignant lymphoma were treated, The program omitted skull radiotherapy and maintenance of the middle, to obtain more satisfactory efficacy, are reported below. 1 Materials and Methods 1.1 Materials 13 cases of acute leaching