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超大剂量程序化疗方案治疗小儿ＡＬＬ１７例，取得良好效果。本方案是根据肿瘤细胞动力学和抗肿瘤药物作用动力学理论制定的。强调药物配伍的治疗顺序和治疗时间的程序性。ＶＡＬＰ诱道治疗：用大剂量ＭＴＸ作冲击治疗：用ＣＰＡ或ＥＭＡ作早期强化；用６—ＭＰ和ＭＴＸ作维持治疗、强调治疗开始２１周时，应用ＶＡＬＤ作再次诱道治疗。强化治疗加用大剂量Ａｒａ—ｃ冲治疗。对普通型ＡＬＬ重视晚期反复强化治疗，对高危型ＡＬＬ重视早期强化治疗。为了保证本方案顺理进行，必须予先克服超大剂量程序化疗产生的血液学毒性和临床学毒性。
Ultra-high-dose chemotherapy program in children treated ALL17 cases, and achieved good results. The program is based on tumor cell kinetics and anti-tumor drug action kinetic theory developed. Emphasize the compatibility of the drug treatment sequence and treatment time procedural. VALP Induction: High-dose MTX for shock therapy: Early-phase boost with CPA or EMA; Maintenance with 6-MP and MTX, emphasizing the reintroduction of VALD for 21 weeks at the start of treatment. Intensive treatment plus large doses of Ara-c Chong treatment. Pay attention to the common type of advanced repeated intensive treatment of ALL, high-risk ALL emphasis on early intensive treatment. In order to ensure that this program goes smoothly, we must first overcome the hematological toxicity and clinical toxicity caused by ultra-high-dose chemotherapy.