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目的评价低剂量亚胺培南/西司他丁钠治疗早产儿呼吸道细菌感染的有效性和安全性。方法选取浙江大学医学院附属妇产科医院2011—2014年收治的早产儿呼吸道细菌感染患儿94例,均给予亚胺培南/西司他丁钠治疗,观察患儿的临床疗效和不良反应。结果治疗后患儿有效率为95.74%,无不良反应发生,分离出的病原菌以革兰阴性菌为主,占95.56%。结论低剂量亚胺培南/西司他丁钠治疗早产儿呼吸道细菌感染的临床疗效显著,不良反应少。
Objective To evaluate the efficacy and safety of low dose imipenem / cilastatin sodium in the treatment of respiratory bacterial infections in preterm infants. Methods 94 cases of respiratory tract bacterial infection in premature infants admitted to Obstetrics and Gynecology Hospital of Zhejiang University School of Medicine from 2011 to 2014 were given imipenem / cilastatin sodium to observe the clinical efficacy and adverse reactions in children . Results After treatment, the effective rate in children was 95.74%, no adverse reactions occurred. Gram-negative bacteria were the main pathogens isolated, accounting for 95.56%. Conclusion The low dose of imipenem / cilastatin sodium in the treatment of respiratory tract bacterial infections in preterm children with significant clinical efficacy, adverse reactions.