每晚服用西咪替丁400毫克作为支持疗法,连续应用4年,治愈了消化性溃疡1842例。急性复发时,每天用西咪替丁1克,连续用12周,后改为每天400毫克支持疗法直到溃疡愈合。在治疗的头一年,每隔6个月作一次内窥镜检查,然后每年作一次。上述病例经分析表明,有症状的溃疡复发率第一年为17.2％,第二年为9.6％,第三年为8.8％;无症状的溃疡复发率分别为8％,5.2％和5.7％。溃疡复发期间,并发症的总比例为1.7％。整个治疗期副作用的发生率从第一年的8％降到4％,以后降为1％。经过二年治疗 Cimetidine 400 mg per night as a supportive therapy, continuous application of 4 years, 1842 cases of peptic ulcer heal. Acute relapse, 1 g of cimetidine daily for 12 weeks, then changed to 400 mg per day supportive therapy until ulcer healing. In the first year of treatment, an endoscopy was performed every 6 months and then once a year. The above cases were analyzed showed that the recurrence rate of symptomatic ulcers in the first year was 17.2%, 9.6% in the second year, 8.8% in the third year; asymptomatic ulcer recurrence rates were 8%, 5.2% and 5.7%. During ulcer recurrence, the overall complication rate was 1.7%. The incidence of side effects throughout the treatment period dropped from 8% in the first year to 4% and later to 1%. After two years of treatment