论文部分内容阅读
用放射免疫法测定８１例妇女血浆及羊水内皮素－１（ＥＴ－１）和前列腺素Ｅ２（ＰＧＥ２）的含量。结果第二产程、潜伏期、正常晚孕、中期妊娠组血浆ＥＴ－１含量均显著高于非孕及产后组，并随妊娠及产程进展逐渐增高，至第二产程达高峰，产后２４ｈ迅速降至非孕时水平。各孕产期羊水ＥＴ－１及ＰＧＥ２含量显著高于血浆中的含量。血浆及羊水ＰＧＥ２浓度随ＥＴ－１的增减而变化，两者呈显著正相关。ＥＴ－１还可通过刺激ＰＧＥ２的生成而在分娩的发动与维持中起重要作用。
The plasma and amniotic fluid levels of endothelin-1 (ET-1) and prostaglandin E2 (PGE2) were measured by radioimmunoassay in 81 women. Results The content of plasma ET-1 in the second stage of labor, latent period, normal late pregnancy and the second trimester pregnancy was significantly higher than that of the non-pregnant and postpartum group, and gradually increased with the progress of pregnancy and labor until the second stage of labor reached its peak. Non-pregnant level. The levels of ET-1 and PGE2 in amniotic fluid during pregnancy were significantly higher than those in plasma. Plasma and amniotic fluid concentrations of PGE2 with ET-1 changes in the changes, both were significantly positive correlation. ET-1 can also play an important role in the initiation and maintenance of labor by stimulating the production of PGE2.