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为了研究心舒口服液对麻醉犬心肌缺血、心肌梗塞及血液流变学的影响,采用心外膜电图标测心肌缺血的范围和程度,以定量组织学(硝基四氮唑蓝染色法)方法测定心肌梗塞范围,同时测定血清 CPK、LDH 的活性和血液流变性变化。结果表明,本口服液具有明显改善犬急性心肌缺血和心梗的作用,减轻心肌缺血的程度(∑-ST)及心肌缺血范围;明显减小梗塞区,显著抑制心肌缺血及心梗所引起的活性升高,有效地降低低切速下的血液粘度,抑制血小板粘附性和聚集性,改善血液流变性。实验结果表明,心舒口服液可用于治疗心肌缺血性冠心病心绞痛及血液高粘滞症。
In order to study the effect of Xinshu oral liquid on myocardial ischemia, myocardial infarction and hemorheology in anesthetized dogs, the extent and degree of myocardial ischemia were measured by epicardial electrical images to quantitative histology (nitrotetrazolium blue staining The method was used to determine the extent of myocardial infarction. Simultaneously, the activities of serum CPK and LDH and the changes of hemorheology were measured. The results show that the oral solution can significantly improve the acute myocardial ischemia and myocardial infarction in dogs, reduce the degree of myocardial ischemia (∑-ST) and myocardial ischemic range; significantly reduce the infarct area, significantly inhibit myocardial ischemia and heart The increased activity caused by stems effectively reduces blood viscosity at low shear rates, inhibits platelet adhesion and aggregation, and improves blood rheology. The experimental results show that Xinshu oral liquid can be used for the treatment of myocardial ischemic coronary heart disease angina and blood hyperviscosity.