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新生儿缺氧缺血性脑损伤是我国新生儿急性死亡和慢性神经系统后遗症的重要原因之一。目前新生儿缺氧缺血性脑药物治疗效果不佳,主要原因是药物无法通过血脑屏障。蛋白质转导结构域(prote in transduction domain,PTD)是指一类能携带其他生物大分子(蛋白多肽、DNA、寡核苷酸等)穿过多种哺乳动物细胞并使其在细胞内积聚的小分子阳离子多肽。PTD能携带生物大分子物质透过血脑屏障(Blood-Brain Barrier,BBB),这为我们研究、治疗中枢神经系统(Central Nervous System,CNS)疾病提供了新的思路。本文就PTD的结构特征、转导过程、与物质连接方式、CNS疾病治疗现状等方面来阐述PTD在新生儿缺氧缺血性脑病中的应用前景。
Neonatal hypoxic-ischemic brain damage is one of the important causes of neonatal acute death and chronic neurological sequelae in China. At present, neonatal hypoxic-ischemic brain drug treatment is not effective, mainly due to drugs can not cross the blood-brain barrier. Proteins transduction domain (PTD) refers to a class of molecules that can carry other biological macromolecules (protein polypeptides, DNA, oligonucleotides, etc.) through a variety of mammalian cells and accumulate them in the cells Small molecule cationic polypeptide. PTD can carry biological macromolecules through the blood-brain barrier (BBB), which provides a new idea for our research and treatment of diseases of the Central Nervous System (CNS). This article describes the structural features of PTD, transduction process, material connections, the status of CNS disease treatment and other aspects to describe the application of PTD in neonatal hypoxic-ischemic encephalopathy.