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为探讨帕金森病（PD）患者体内抗氧化系统水平及其在PD发病中的作用，对70例PD患者血浆维生素C（P－VC）、维生素E（P－VE）、血浆及红细胞超氧化物歧化酶（P－SOD，E－SOD）、血浆与红细胞过氧化脂质（P－LPO，E－LPO）的水平进行了检测并与正常对照组比较。结果表明：PD组P-VC、P-VE水平及P-SOD、E-SOD活性均比正常对照组显著降低，而P-LPO、E-LPO则显著增高，并且P-VC、P-VE、E-SOD与病情和病程呈负相关，提示抗氧化系统缺陷及内源性氧自由基堆积与PD发病有密切关系。
To investigate the antioxidant system and its role in the pathogenesis of PD in patients with Parkinson’s disease (PD), the levels of plasma vitamin C (P-VC), vitamin E (P-VE), plasma and erythrocyte superoxidation The levels of P-SOD and E-SOD, plasma and erythrocyte lipid peroxidation (P-LPO, E-LPO) were measured and compared with the normal control group. The results showed that the levels of P-VC, P-VE and the activities of P-SOD and E-SOD in PD group were significantly lower than those in normal control group, but P-LPO and E-LPO were significantly increased , E-SOD was negatively correlated with the disease and course of disease, suggesting that antioxidant system defects and accumulation of endogenous oxygen free radicals are closely related to the pathogenesis of PD.