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目的提高对罕见的肝脏原发性肿瘤—肝脏腺鳞癌的诊疗水平。方法采用文献检索收集1975-2007年间报道的包括北京大学人民医院1例在内资料齐全的原发性肝脏腺鳞癌病人47例,总结其病例资料,对原发性肝脏腺鳞癌的临床特点、影像学资料、治疗及预后进行回顾性分析。结果47例病人中多数病人无法在术前得到确诊,一些病人在术后早期即可出现远处淋巴结和(或)肝内转移,截至2007年底已有42例死于原发疾病,平均生存时间约7.3个月。多因素分析提示术前淋巴结转移、病理分级与预后不佳有关。结论原发性肝脏腺鳞癌是一种预后较差的肝脏罕见恶性肿瘤,术前难以与其他肝脏肿瘤区别,应提高对其认识和诊疗水平。
Objective To improve the diagnosis and treatment of liver adenosquamous carcinoma, a rare primary liver tumor. Methods A total of 47 patients with primary liver adenosquamous carcinoma, including one case of Peking University People’s Hospital, reported from 1975 to 2007 were collected by literature search. The clinical data of primary liver adenosquamous carcinoma , Imaging data, treatment and prognosis were retrospectively analyzed. Results Most of the 47 patients could not be diagnosed preoperatively. Some patients showed distant lymph nodes and / or intrahepatic metastasis in the early postoperative period. As of the end of 2007, 42 patients died of primary disease, the mean survival time About 7.3 months. Multivariate analysis suggested preoperative lymph node metastasis, pathological grading and poor prognosis. Conclusions Primary liver adenosquamous carcinoma is a rare malignant tumor of liver with poor prognosis. It is difficult to distinguish it from other liver tumors before surgery, and its awareness and diagnosis should be improved.