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建立厌氧菌及需氧菌混合感染的大鼠急性化脓性腹膜炎模型，并观察消炎痛对其死亡率、腹腔脓肿形成率、腹腔脓肿大小及腹腔粘连率的影响；还观察了其单核细胞生成ＰＧＥ＿２能力的变化。结果发现，消炎痛可降低脓肿形成率、减少脓肿体积、降低粘连形成率并抑制ＰＧＥ＿２的生成，统计学差异有显著性意义（Ｐ＜０．０５或Ｐ＜０．０１）；但消炎痛对死亡率的影响不显著（Ｐ＞０．０５），死亡率仅有下降的趋势。
To establish an acute suppurative peritonitis model of mixed infection of anaerobic bacteria and aerobic bacteria in rats, and observe the effect of indomethacin on its mortality, the rate of abdominal abscess formation, the size of abdominal abscess and the rate of abdominal adhesion; also observed the mononuclear cells The ability to generate PGE_2 changes. The results showed that indomethacin can reduce the rate of abscess formation, reduce the volume of abscess, reduce the formation rate of adhesion and inhibit the formation of PGE_2, the statistical difference was significant (P <0.05 or P <0.01); but indomethacin The effect of mortality was not significant (P> 0.05), and the mortality rate only decreased.