论文部分内容阅读
目的:总结分化相关基因NDRG1的研究进展,探讨NDRG1在肿瘤等疾病治疗中的应用价值。方法:应用PubMed和CNKI期刊全文数据库检索系统,以“NDRG1、肿瘤转移、细胞分化”为关键词,共检索到1997-2010年相关文献159篇,纳入标准:1)NDRG1的表达及调控;2)NDRG1在肿瘤中的表达及临床意义。根据标准纳入分析30篇参考文献。结果:NDRG1属NDRG家族成员,受p53、PTEN和缺氧等多种因素调控,主要参与细胞的生长发育和分化、成熟,近年发现,NDRG1与人类肿瘤的发生发展、侵袭及转移密切相关,是影响恶性肿瘤预后的新指标。结论:有关NDRG1的研究可能为肿瘤预后判断及分化治疗提供新的依据。
OBJECTIVE: To summarize the research progress of differentiation-related gene NDRG1 and to explore the value of NDRG1 in the treatment of cancer and other diseases. Methods: PubMed and CNKI journal full-text database retrieval system was used to search for 159 articles from 1997 to 2010 with the keywords of “NDRG1, tumor metastasis and cell differentiation”. The inclusion criteria were as follows: 1) NDRG1 expression and regulation ; 2) NDRG1 expression in tumor and its clinical significance. According to the standard inclusion analysis of 30 references. Results: NDRG1 is a member of the NDRG family. It is regulated by many factors such as p53, PTEN and hypoxia. It is mainly involved in the growth, differentiation and maturation of cells. Recently, NDRG1 has been found to be closely related to the development, invasion and metastasis of human tumors New prognostic indicators of malignancy. Conclusion: The research on NDRG1 may provide a new basis for judgment of tumor prognosis and differentiation treatment.