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目的为观察绝经后骨质疏松妇女应用益钙宁长期治疗４８周至７２周对骨密度（ＢＭＤ）及骨转换生化指标的影响。方法３３例患者应用益钙宁（２０单位／次，１次／周）加乳酸钙（元素钙，５００ｍｇ／日）治疗，另３５例患者单纯用乳酸钙（元素钙５００ｍｇ／日）治疗。结果应用益钙宁加钙治疗组患者腰椎２～４ＢＭＤ在治疗２４周始即有明显增加并持续至７２周；股骨近端的ＢＭＤ增加，Ｗａｒｄｓ三角区部位见于２４周到４８周；股骨颈部位见于４８周和７２周；大转子部位仅在７２周。血ＢＧＰ水平治疗２４周呈增高的改变，而血ＴＲＡＰ和尿ＨＹＰ／Ｃｒ比值的改变于治疗２４周、４８周和７２周均有明显的下降。单纯用钙对照组于治疗后与治疗前比较未见明显改变。结论本研究结果提示益钙宁长期治疗可抑制骨吸收并可能刺激骨形成，预防骨量丢失并增加骨量
Objective To observe the effect of long-term therapy of YG on the bone mineral density (BMD) and biochemical markers of bone turnover in postmenopausal women with osteoporosis for 48 weeks to 72 weeks. Methods 33 patients were treated with YG (20 units / time, once a week) plus calcium lactate (500 mg / day), and the other 35 patients were treated with calcium lactate alone (500 mg / day). Results In patients treated with YGC plus calcium, the 2 ~ 4BMD of lumbar vertebrae increased significantly at the beginning of 24 weeks of treatment and continued to 72 weeks. The BMD of the proximal femur increased from 24 weeks to 48 weeks in Wards triangle, Seen at 48 weeks and 72 weeks; greater trochanter site only 72 weeks. Serum BGP levels increased at 24 weeks, while changes in blood TRAP and urine HYP / Cr levels were significantly reduced at 24, 48, and 72 weeks of treatment. Simple calcium control group after treatment compared with before treatment no significant change. Conclusions The results of this study suggest that long-term treatment with YG can inhibit bone resorption and may stimulate bone formation, prevent bone loss and increase bone mass